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Non-steroidal anti-inflammatory drugsIn some patientsthe administration of a non-steroidal anti-inflammatory agent can reduce the diureticnatriureticand antihypertensive effects of looppotassium-sparing and thiazide diureticsWhen MICROZIDEhydrochlorothiazide capsuleand non-steroidal anti-inflammatory agents are used concomitantlythe patients should be observed closely to determine if the desired effect of the diuretic is obtained.
Your age the condition being treated how severe your condition is other medical conditions you have how you react to the first dose.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Renal DiseaseCumulative effects of the thiazides may develop in patients with impaired renal functionIn such patientsthiazides may precipitate azotemia.
Lithiumgenerally should not be given with diureticsDiuretic agents reduce the renal clearance of lithium and greatly increase the risk of lithium toxicityRefer to the package insert for lithium preparations before use of such preparations with MICROZIDEhydrochlorothiazide capsule
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